The paths of a desperate man and an imprisoned young woman cross unexpectedly in the den of a mysterious killer.

The film follows John Crenshaw as he accompanies his girlfriend and her students on a weekend nature-photography expedition deep into the woods. What should be an educational and fun-filled weekend turns into horror as the group is besieged by an unspeakable evil - a horde of hideously disfigured, mutated humans with an insatiable taste for blood. As things go from bad to worse, Crenshaw becomes their only hope if they are going to get out alive.

The year is 1879. Gunfighters and cardsharps from the far reaches of the globe descend on the mining town of Religion, Arizona to compete in a legendary poker tournament. Drawn to town by the gold prize, the players come to realize that in this game their very souls are at stake.